The goal of this study was to evaluate the relationship between ambient hexavalent chromium concentration and the concentration of the chromium in-whole blood, plasma, erythrocytes, and its urinary excretion of male rats after inhalation exposure of sodium chromate during 1, 2, and 3 weeks.
1. Differences of mean chromium concentration in urine, whole blood, erythorocytes, and plasma of male rats exposed to sodium chromate by exposure level were statistically significance, respectively.
2. At low and high exposure groups, differences of mean chromium concentration in urine, whole blood, erythrocytes, and plasma of male rats by duration of inhalation exposure were statistically significance, respectively.
3. Ratio of whole blood chromium to plasma chromium increased with the incrased duration of inhalation expousre of sodium chromate.
4. Ambient hexavalent chromium was positively and strongly correlated with in erythrocyte chromium, and also erythrocyte chromium was strongly correlated with in whole blood chromium.
In conclusion, this study showed that chromium in erythrocyte increased with the increased exposure level and exposure duration, therefore this study suggest that chromium in erythrocytes is a good biological exposure index of the internal dose from exposure to soluble hexavalent chromium compound.
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